The Interstates of Upstate New York make direct connections with the Connecticut and Massachusetts turnpikes, New Jersey's Garden State Parkway and other major expressways that lead to New England, Canada, the Midwest and the South.

The Governor Thomas E. Dewey Thruway, the 641-mile superhighway crossing New York State, is the longest toll superhighway system in the United States. The Thruway's 426-mile mainline connects New York City and Buffalo, the state's two largest cities. A majority of New York State's 62 cities, including the nine largest, are located within the Thruway corridor, which contains more than 80 percent of the state's population..

Driving Distance Table (Buffalo, Syracuse, and Albany)